Impact of Sex and Genetic Variation in Relevant Pharmacogenes on the Pharmacokinetics and Safety of Valsartan, Olmesartan and Hydrochlorothiazide

Pubmed-Investigación, Sin categoría

Int J Mol Sci. 2023 Oct 17;24(20):15265. doi: 10.3390/ijms242015265. ABSTRACT Drug combination therapy is the most common pharmacological strategy for hypertension management. No pharmacogenetic biomarkers for guiding hypertension pharmacotherapy are available to date. The study population were 64 volunteers from seven bioequivalence trials investigating formulations with valsartan, olmesartan and/or hydrochlorothiazide. Every volunteer was genotyped for…

Frecuencias de alelos farmacogenómicos entre grupos biogeográficos en el biobanco del Reino Unido

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Para garantizar la eficacia de la farmacogenética en la atención clínica, es esencial considerar diversos haplotipos/diplotipos. El auge de los biobancos genéticos a nivel mundial ofrece la oportunidad de comprender las frecuencias de distintos alelos farmacogenéticos en diversas poblaciones. En este estudio (Li B, et al. Frequencies of pharmacogenomic alleles across biogeographic groups in a…

Academia and industry agreement on a feasibility tool for first-time-in-human clinical trial units

Pubmed-Investigación, Sin categoría

Clin Transl Sci. 2023 Oct 11. doi: 10.1111/cts.13655. Online ahead of print. ABSTRACT First-time-in-human (FTIH) trials are designed to generate information on the safety, tolerability, as well as the pharmacokinetic and pharmacodynamics profile of new drugs. To ensure the safety of participants, these trials need to be conducted at specifically equipped phase I clinical trial…

Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis

Pubmed-Investigación, Sin categoría

Front Med (Lausanne). 2023 Sep 22;10:1215246. doi: 10.3389/fmed.2023.1215246. eCollection 2023. ABSTRACT INTRODUCTION: SARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity. MATERIALS AND METHODS: Retrospective observational study…