Identification of Transporter Polymorphisms Influencing Metformin Pharmacokinetics in Healthy Volunteers

J Pers Med. 2023 Mar 8;13(3):489. doi: 10.3390/jpm13030489. ABSTRACT For patients with type 2 diabetes, metformin is the most often recommended drug. However, there are substantial individual differences in the pharmacological response to metformin. To investigate the effect of transporter polymorphisms on metformin pharmacokinetics in an environment free of confounding variables, we conducted our study…