Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
Metabolism. 2022 Dec;137:155335. doi: 10.1016/j.metabol.2022.155335. Epub 2022 Oct 19. ABSTRACT BACKGROUND: Second-generation antipsychotics (SGAs) are a mainstay therapy for schizophrenia. SGA-treated patients present higher risk for weight gain, dyslipidemia and hyperglycemia. Herein, we evaluated the effects of olanzapine (OLA), widely prescribed SGA, in mice focusing on changes in body weight and energy balance. We further…
