Association between CYP2C19 and CYP2B6 phenotypes and the pharmacokinetics and safety of diazepam
Biomed Pharmacother. 2022 Nov;155:113747. doi: 10.1016/j.biopha.2022.113747. Epub 2022 Sep 24. ABSTRACT Diazepam is a benzodiazepine (BZD) used worldwide for a variety of conditions. Long-term use of diazepam increases the risk for developing tolerance and dependence and for the occurrence of adverse drug reactions (ADRs). CYP3A4 and CYP2C19 mainly metabolize diazepam and are therefore the primary…
