CYP2C18: the orphan in the CYP2C family
Pharmacogenomics. 2022 Nov;23(17):913-916. doi: 10.2217/pgs-2022-0142. Epub 2022 Nov 4. NO ABSTRACT PMID:36331025 | DOI:10.2217/pgs-2022-0142
CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride
Clin Transl Sci. 2022 Nov;15(11):2613-2624. doi: 10.1111/cts.13386. Epub 2022 Sep 6. ABSTRACT Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease. In this study, we aimed to explore the impact of relevant variants in CYP3A4 and CYP2C8 and other pharmacogenes, along with…
Association between CYP2C19 and CYP2B6 phenotypes and the pharmacokinetics and safety of diazepam
Biomed Pharmacother. 2022 Nov;155:113747. doi: 10.1016/j.biopha.2022.113747. Epub 2022 Sep 24. ABSTRACT Diazepam is a benzodiazepine (BZD) used worldwide for a variety of conditions. Long-term use of diazepam increases the risk for developing tolerance and dependence and for the occurrence of adverse drug reactions (ADRs). CYP3A4 and CYP2C19 mainly metabolize diazepam and are therefore the primary…
