Population pharmacokinetic modelling of imatinib in healthy subjects receiving a single dose of 400 mg

Pubmed-Investigación

Cancer Chemother Pharmacol. 2022 Aug;90(2):125-136. doi: 10.1007/s00280-022-04454-y. Epub 2022 Jul 14. ABSTRACT PURPOSE: Imatinib is indicated for treatment of CML, GIST, etc. The population pharmacokinetics (popPK) of imatinib in patients under long-term treatment are reported in literature. Data obtained from bioequivalence trials for healthy subjects were used to evaluate the influence of demographic and pharmacogenetic…

Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis

Pubmed-Investigación

Front Cardiovasc Med. 2022 Aug 4;9:959916. doi: 10.3389/fcvm.2022.959916. eCollection 2022. ABSTRACT OBJECTIVE: To date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial. Hence, a systematic review was performed to study the association between CES1 rs2244613 genotype and the PKs and safety of dabigatran and…