Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity

Pubmed-Investigación

Life Sci Alliance. 2022 May 30;5(10):e202201396. doi: 10.26508/lsa.202201396. Print 2022 Oct. ABSTRACT By the end of December 2021, coronavirus disease 2019 (COVID-19) produced more than 271 million cases and 5.3 million deaths. Although vaccination is an effective strategy for pandemic control, it is not yet equally available in all countries. Therefore, identification of prognostic biomarkers…

Pharmacogenetics of Donepezil and Memantine in Healthy Subjects

Pubmed-Investigación

J Pers Med. 2022 May 13;12(5):788. doi: 10.3390/jpm12050788. ABSTRACT Donepezil and memantine are the most common drugs used for Alzheimer’s disease. Their low effectiveness could partly be explained by genetic factors. Thus, we aim to identify Single Nucleotide Polymorphisms (SNPs) associated with pharmacokinetics, pharmacodynamics, and the safety of donepezil and memantine. For this regard, 25…