Sci Rep. 2021 Jul 16;11(1):14579. doi: 10.1038/s41598-021-93780-x. ABSTRACT The interplay between T cells, dendritic cells and keratinocytes is crucial for the development and maintenance of inflammation in psoriasis. GADD45 proteins mediate DNA repair in different cells including keratinocytes. In the immune system, GADD45a and GADD45b regulate the function and activation of both T lymphocytes and…
Front Pharmacol. 2021 Jul 14;12:711940. doi: 10.3389/fphar.2021.711940. eCollection 2021. ABSTRACT Olanzapine, aripiprazole and risperidone are atypical antipsychotics or neuroleptics widely used for schizophrenia treatment. They induce various adverse drug reactions depending on their mechanisms of action: metabolic effects, such as weight gain and alterations of glucose and lipid metabolism; hyperprolactinemia and extrapyramidal effects, such as…
Adv Ther. 2021 Jul;38(7):4070-4081. doi: 10.1007/s12325-021-01801-y. Epub 2021 Jun 12. ABSTRACT INTRODUCTION: Bilastine is a second-generation H1 antihistamine indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. On the basis of the demonstrated efficacy and safety of the oral formulation, a new ophthalmic formulation of bilastine was recently developed. Previous preclinical studies had indicated…
